RDC is composed of four parts, including radionuclide, chelator, linker, and targeting biomolecule. After the connection between radioactive particle and chelator, this complex needed to binding to the targeting molecule by a linker to avoid interferences between bioactive groups in RDC. The linker in the RDC, also named as PKM (Pharmacokinetic Modifying) linker, has a significant effect on radiotracer excretion kinetics of RDC to improve the T/B (target-to-background) ratios of the radiopharmaceutical. https://www.rdcthera.com/linke....r-design-and-synthes
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